The MMP20 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to MMP20. This antibody recognizes Human antigen. The MMP20 Antibody has been validated for the following applications: ELISA, and Western Blot.
Description
Function: Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the '360-Asn-:-Phe-361' site.
Post-translational Modifications: Autoactivates at least at the 107-Asn-:-Tyr-108 site.
Similarity: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme. Belongs to the peptidase M10A family